Rebecca Mister

Timothy A. Brighton, M .B., B.S., John W. Eikelboom, M.B., B.S., Kristy Mann, M.Biostat., Rebecca Mister, M.Sc., Alexander Gallus, M.B., B.S., Paul Ockelford, M.B., Harry Gibbs, M.B., Wendy Hague, Ph.D., Denis Xavier, M.Sc., Rafael Diaz, M.D., Adrienne Kirby, M.Sc., and John Simes, M.D. For the ASPIRE Investigators: Low-Dosage Aspirin for Avoiding Recurrent Venous Thromboembolism Patients who have had a first bout of unprovoked venous thromboembolism are in risky for recurrence after anticoagulant therapy is discontinued.1-4 Long-term treatment with a vitamin K antagonist is very effective in preventing a recurrence of venous thromboembolism while treatment continues5 but is not proven to improve survival, is connected with a substantially increased risk of bleeding, and is inconvenient for sufferers.6-10 Consequently, many patients who have had a first episode of unprovoked venous thromboembolism discontinue anticoagulant therapy following 3 to 6 months despite recommendations to prolong therapy.5 Low-dose aspirin is definitely a straightforward, inexpensive, and accessible treatment that is effective for the prevention of arterial vascular events and for the principal prevention of venous thromboembolism in high-risk surgical individuals.11-13 Aspirin may also be effective in preventing a recurrence of venous thromboembolism after a first event.14 The objective of our research was to evaluate the efficacy of low-dose aspirin, in comparison with placebo, in preventing a recurrence of venous thromboembolism in sufferers who had completed initial anticoagulation with warfarin after an initial unprovoked bout of venous thromboembolism.

Monotherapy with isoniazid was studied through the entire 1950s, and in those scholarly research, significantly less than 32 percent of patients had sputum-culture conversion through the first three months of treatment.35 First-line quadruple drug therapy has been connected with a mean time to culture conversion on solid medium of 30 to 40 days.36,37 In sufferers with MDR tuberculosis who were treated with second-line agents, the conversion rate was lower substantially, and the time to conversion was longer. For example, in a recent study that used a five-drug routine , significantly less than 10 percent of patients had a poor culture after 2 months.38 In larger research involving individuals with MDR tuberculosis, the estimated median time to culture conversion was 63 days.39 Linezolid alone would therefore look like like the five-drug chemotherapy regimen currently utilized as second-line treatment, and the incorporation of linezolid into second-line regimens may considerably improve culture-conversion rates.