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The mean baseline hemoglobin level and iron status were similar across groupings in both studies. The median duration of follow-up for the peginesatide groups combined and the groups receiving darbepoetin were 81.4 weeks and 82.1 weeks , respectively, in PEARL 1 and 67.9 weeks and 70.1 weeks , respectively, in PEARL 2 . Dosages were adjusted relative to the average person hemoglobin response and tended to converge over time in the peginesatide organizations. The median of the mean dosage administered per affected individual during longer-term follow-up for the organizations receiving the low starting dosage of peginesatide, the bigger starting dosage of peginesatide, and darbepoetin was 1.6 mg, 1.9 mg, and 29.5 mg, 1.6 mg, and 25.87 g per deciliter, 1.97 g per deciliter, and 1.86 g per deciliter, respectively, in PEARL 1 and 1.90 g per deciliter, 1.96 g per deciliter, and 1.00 g per deciliter, respectively, in PEARL 2.