Abdelilah el Barzouhi, M.D., Carmen L.A.M. Vleggeert-Lankamp, M.D., Ph.D., Geert J.D., Ph.D., Bas F. Van der Kallen, M.D., Wilbert B. Van den Hout, Ph.D., Wilco C.H. Jacobs, Ph.D., Bart W. Koes, Ph.D., and Wilco C. Peul, M.D., Ph.D.1 The most common cause of sciatica is a herniated disk. The natural history of sciatica is certainly favorable, with spontaneous quality of leg discomfort within 8 weeks in nearly all patients. 2 Surgery should be offered only when symptoms persist after a period of conservative treatment. Nevertheless, contrary to what one might anticipate, given the advancements in diagnostic imaging and surgical techniques, the total effects after lumbar-disk surgery do not seem to have improved during recent decades.Using new research methods on rats, Bruno’s laboratory has discovered that the neuronal connections bridging the thalamus to the cortex are not only massively plastic, but they grow and retract rather in only a couple of days in response to different sensations rapidly. The rapidity of this growth is actually striking-it happens in a matter of three days, which is something no one previously thought was possible. Those kinds of rapid physical changes also most likely occur in other areas of the brain as well. In fact, certain conditions accelerate this physical, chemical and functional remodeling of the brain. Said Michael Merzenich, Emeritus Professor at the Keck Middle for Integrative Neurosciences at the University of California at San Francisco, and Director and founder of the mind Plasticity Institute, In our experiments in adult rats, changes just occurred when the animal was attentive within a rewarded learning environment.