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Gallen consensus tips for individuals with operable node-negative breast malignancy .14 Patients underwent randomization within 60 days after medical procedures to get TAC or FAC relating to a center-particular randomization block. Randomization was centralized and stratified for the participating organization and for menopausal position. Treatment On day 1 of each of six 21-day treatment cycles, patients received an intravenous infusion of either TAC or FAC . To avoid edema, patients in the TAC group received a standard dosage of dexamethasone before receiving the study treatment. Main prophylactic antibiotic therapy was mandatory during all cycles for individuals receiving TAC. Main prophylaxis with granulocyte colony-stimulating factor was not permitted in the initial protocol.